An unusual base-mediated ring contraction reaction of benzopyrans to benzofurans

Add time:08/29/2019    Source:sciencedirect.com

The reaction of electron deficient pyrroles and pyrazoles with trans-3-bromo-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-ol under basic conditions results in the formation of 2-isopropylbenzofurans by a mechanism which appears to be dependent on the rate of the competitive dehydration reaction leading to the corresponding benzopyrans.

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