Short communicationNitric oxide scavenger carboxy-PTIO (cas 18390-00-6) potentiates the inhibition of dopamine uptake by nitric oxide donors

Add time:09/01/2019    Source:sciencedirect.com

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) has been increasingly used as nitric oxide (NO) scavenger. Carboxy-PTIO reacts with NO to form nitric dioxide and 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl (carboxy-PTI). In rat C6 glioma cells expressing human dopamine transporter, carboxy-PTIO paradoxically potentiated the inhibition of [3H]dopamine uptake by two NO donors, diethylamine/NO and (Z)-1-[N-(3-ammoniopropyl)-N-(n-propyl)-amino]/NO. Further examinations revealed that carboxy-PTI concentration-dependently reduced dopamine uptake, indicating that the formation of carboxy-PTI may account for the failure of carboxy-PTIO to abolish NO elicited effects. These results suggest that caution should be taken in interpreting data obtained using carboxy-PTIO and probably other NO scavengers.

We also recommend Trading Suppliers and Manufacturers of PTIO (cas 18390-00-6). Pls Click Website Link as below: cas 18390-00-6 suppliers

Prev:Original ContributionInterference of Carboxy-PTIO (cas 18390-00-6) with Nitric Oxide- and Peroxynitrite-Mediated Reactions
Next:EFFECT OF THE NO SCAVENGER CARBOXY-PTIO (cas 18390-00-6) ON ENDOTHELIUM-DEPENDENT VASORELAXATION OF VARIOUS BLOOD VESSELS FROM RABBITS)