Transition metal-catalyzed CH functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides
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Add time:09/05/2019 Source:sciencedirect.com
Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves CH functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approach furnished benzothiadiazine 1,1-dioxide derivatives in good to excellent yields. Broad substrate scope, inexpensive catalyst and high product yields are notable features of this protocol.
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