Short communicationEndothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+channel antagonist., in canine mesenteric arteries

Add time:08/30/2019    Source:sciencedirect.com

Modulation of the vasoinhibitory effect of NKY-722 by vascular endothelial cells was studied in canine mesenteric arteries. A high concentration of NKY-722 accumulated in the endothelium-intact arteries and its accumulation in endothelium-removed arteries was significantly less. The vasoinhibitory effect of NKY-722 in endothelium-intact arteries was significantly weaker than that in endothelium-removed arteries. These results suggest that endolhelial cells can attenuate the vasoinhibitory effect of NKY-722.

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