Original articleSynthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives

Add time:08/30/2019    Source:sciencedirect.com

A new series of aromatic ester and carbamate derivatives of 2-(1H-imidazol-1-yl)-1-phenylethanol were synthesized and evaluated for their antifungal activity towards Candida albicans and non-albicans Candida species strains. The aromatic biphenyl ester derivatives 6a–c were more active than the reference compound fluconazole. 6c possesses a MIC mean values of 1.7 ± 1.4 μg mL−1 vs C. albicans and 1.9 ± 2.0 μg mL−1 vs non-albicans Candida species strains. The racemic mixtures of 6a, b were purified to afford the pure enantiomers. The (−) isomers were up to 500 times more active than (+) isomers. (−)-6a and (−)-6b were thirty and ninety times more active than fluconazole towards C. krusei strain respectively.The racemates of 6a–c showed low cytotoxicity against human monocytic cell line (U937) with 6a demonstrating a CC50 greater than 128 μg mL−1.

We also recommend Trading Suppliers and Manufacturers of Ethyl 2-(1H-iMidazol-1-yl)benzoate (cas 117296-92-1). Pls Click Website Link as below: cas 117296-92-1 suppliers

Prev:Vapor–liquid equilibria in the systems 3-methylpentane+methyl 1,1-dimethylethyl ether and 3-methylpentane+methyl 1,1-dimethylpropyl ether at 101.3 kPa
Next:Functionalized bis(1-methylimidazol-2-yl)methane and 1-(1-methylimidazol-2-yl)methyl-3,5-dimethylpyrazole and their reactions)