Methionine uptake by larval and adult Schistosoma mansoni

Add time:09/01/2019    Source:sciencedirect.com

The uptake of methyl-14C-methionine by schistosomula, 21 day-old and adult Schistosoma mansoni in vitro has been investigated. Ligation of the adult pharynx and comparison between the kinetics of uptake of schistosomula and adults suggests that methionine is absorbed, in the system described, primarily via the tegument. All stages of the parasite examined absorb methionine by, at least, two kinetically distinguishable systems, one which is saturable and a second which appears to be simple diffusion. The saturable system has relatively low specificity for amino acids but shows no affinity for other classes of compounds. The effects of pH, temperature, metabolic inhibitors, and sodium ion concentration have been examined. The results are discussed with reference to schistosome gut function and also to the differential response to chemotherapy according to age of infection.

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