Acidic steroid metabolites: Evidence for the excretion of C-21-carboxylic acid metabolites of progesterone in rabbit urine

Add time:07/15/2019    Source:sciencedirect.com

Acidic metabolites of injected progesterone have been isolated from rabbit urine. The acids were chromatographed on alumina and florisil columns, precipitated as salts, methylated and oxidised to give a simplified pure oxosteroid fraction. Gas chromatography on 3% SE-30 gave a major compound that was characterised as 3,6,20-trioxo-5α-pregnan-21-oic acid methyl ester by comparison with the synthesised compound. No evidence for 5β- or dioxosteroids was found indicating that the steroid acids are exclusively trioxygenated-5α-pregnanes. This is the first reported isolation of a C-21-carboxylic acid metabolite of progesterone.

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