Toxic and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl (CB-77) and clophen A50 on eider duckling (Somateria mollissima) in a semi-field experiment☆

Add time:09/01/2019    Source:sciencedirect.com

In this study the possible toxic and biochemical effects of one intraperitoneal dose of 5 or 50 mg kg−1 of 3,3′,4,4′-tetrachlorobiphenyl (CB-77) or 50 or 200 mg kg−1 of Clophen A50 (CloA50) on 28-day-old eider ducklings (Somateria mollissima) were investigated. After ten days, no significant differences could be observed in any of the toxic and biochemical parameters studied, apart from ethoxyresorufin (EROD) activity, when comparing group average values of the dosed and control animals. However, significant correlations were observed at day 10 after exposure between the individual internal PCB concentration and body weight gain and beak length growth (negative correlations in the CloA50 groups); relative liver weight and cytochrome P4501A activity (positive correlations in CB-77 and CloA50 groups); plasma thyroid-hormone and hepatic retinoid levels (negative correlations in CB-77 groups); and plasma retinol levels and the ratio plasma retin/hepatic retinyl palmitate (positive correlations in CB-77 groups only). Animal activity was significantly reduced in the group that received 50 mg CB-77 kg−1. These observations indicate that eider ducks are a sensitive species to PCB toxicity and may be at risk for development of adverse health effects in relatively highly contaminated areas such as the Waddenzee.

We also recommend Trading Suppliers and Manufacturers of CLOPHEN A 30 : A 60 1 : 1 (cas 1336-36-3). Pls Click Website Link as below: cas 1336-36-3 suppliers

Prev:Low hepatic 7-ethoxyresorufin-O-deethylase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50
Next:Effects of clophen A50 on the metabolism of paranitroanisole in an in vitro perfused rainbow trout liver)