Diastereoselective construction of azetidin-2-ones by electrochemical intramolecular C–C bond forming reaction

Add time:07/14/2019    Source:sciencedirect.com

A convenient method for synthesis of optically active azetidin-2-ones using electrochemical oxidation has been exploited. The method consists of a diastereoselective intramolecular C–C bond forming reaction between active methylene and methyne groups through an electrochemical system in which positive iodine species acted as mediators under mild conditions.

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