New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter (cas 136253-20-8)
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Add time:08/31/2019 Source:sciencedirect.com
A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.
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