Welcome to LookChem.com Sign In | Join Free

Science Details

Home > Chemical Encyclopedia > Science List > Details
  • Tiotropium bromide (cas 136310-93-5) inhibits relapsing allergic asthma in BALB/c mice☆

  • Add time:09/03/2019    Source:sciencedirect.com

    Recurrent relapses of allergic lung inflammation in asthmatics may lead to airway remodeling and lung damage. We tested the efficacy of Tiotropium bromide (cas 136310-93-5), a selective long-acting, muscarinic receptor antagonist as an adjunct therapy in relapses of allergic asthma in mice. We compared the effectiveness of local intranasal administration of tiotropium and dexamethasone in acute and relapsing allergic asthma in BALB/c mice. Although tiotropium at low doses is a potent bronchodilator, we tested higher doses to determine effectiveness on inflammation and mucus hypersecretion. A 5-day course of twice daily intranasal tiotropium or dexamethasone (1 mg/kg (b.w.)) suppressed airway eosinophils by over 87% during disease initiation and 88% at relapse compared to vehicle alone. Both drugs were comparable in their capacity to suppress airway and parenchymal inflammation and mucus hypersecretion, though tiotropium was better than dexamethasone at reducing mucus secretion during disease relapse. Despite treatment with either drug, serum antigen-specific IgE or IgG1 antibody titres remained unchanged. Our study indicates that tiotropium at higher doses than required for bronchodilation, effectively suppresses inflammation and mucus hypersecretion in the lungs and airways of mice during the initiation and relapse of asthma. Tiotropium is currently not approved for use in asthma. Clinical studies have to demonstrate the efficacy of tiotropium in this respiratory disease.

    We also recommend Trading Suppliers and Manufacturers of Tiotropium bromide (cas 136310-93-5). Pls Click Website Link as below: cas 136310-93-5 suppliers

    Prev:Original articleComparison of the rapid effects of single inhalations of formoterol and Tiotropium bromide (cas 136310-93-5) on respiratory function and COPD symptoms in a randomized crossover study
    Next:ReviewsTiotropium bromide (cas 136310-93-5))

  • Back】【Close 】【Print】【Add to favorite
Periodic Table
    Related Products