Original articleA novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism

Add time:08/30/2019    Source:sciencedirect.com

A new regioselective method for the synthesis of 2-aryl-5-benzoylpyridine derivatives has been developed. The reaction proceeds via ring opening and closing cascade mechanism (ROCC) of isoxazole to synthesize various functionalized pyridine derivatives. This is the first report for the preparation of 2,5-di-substituted pyridines using Fe/NH4Cl as a reducing reagent.

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