Spin-trapping of free radicals formed during microsomal metabolism of ethylhydrazine (cas 18413-14-4) and acetylhydrazine

Add time:09/02/2019    Source:sciencedirect.com

Radicals formed during oxidative metabolism of ethylhydrazine (cas 18413-14-4) have been spin-trapped with PBN1. The trapped species has been identified as an ethyl radical by comparison of the ESR parameters of the PBN-adduct with (1) those of the analogous adduct formed during CuCl2-catalyzed oxidation of ethylhydrazine and (2) those reported for the adduct in the literature. The requirement for oxygen and NADPH, and the observation of a typical binding spectrum by difference spectroscopy, suggest the involvement of the cytochrome P-450 enzyme system in radical formation. Similar studies with acetylhydrazine demonstrate the generality of metabolic radical formation from hydrazines, although the radical trapped in this latter instance has not been identified.

We also recommend Trading Suppliers and Manufacturers of ethylhydrazine (cas 18413-14-4). Pls Click Website Link as below: cas 18413-14-4 suppliers

Prev:An ab initio gradient study of ethylhydrazine (cas 18413-14-4)
Next:Coordination compounds of ethylhydrazine (cas 18413-14-4) and 2,2,2-Trifluoroethylhydrazine (cas 18413-14-4); crystal and molecular structure of dichlorotetrakis(2,2,2-Trifluoroethylhydrazine (cas 18413-14-4)) nickel(II))