Synthesis and crystal structure of quinolinium salt: Assignment on nonsteroidal anti-inflammatory activity and DNA cleavage activity

Add time:09/02/2019    Source:sciencedirect.com

To develop new anti-inflammatory and DNA cleavage agent with improved pharmaceutical profile, five quilinium salt based compounds have been synthesized and x-ray characterization of these quinolinium salts have been reported here. These quinolinium salts have potential to show the better anti-inflammatory activity as well as DNA cleavage activity. The anti-inflammatory activities of quinolinium salts 1–5 have been evaluated by complete Freund's adjuvant (CFA) induced rat paw edema method. The DNA cleavage activities of quinolinium salts 1–5 were analyzed by using plasmid pBR322. The crystal structure of quinolium salt 1, 2 and 3 have shown the intermolecular non-covalent interactions such as cation···π, π···π, CH···π, CH···X (X = I and Br) and CH⋯N interactions.

We also recommend Trading Suppliers and Manufacturers of Quinolinium, 1-methyl-2-(2-((3-methyl-2(3H)-benzothiazolylidene)methyl )-1-butenyl)-, iodide (cas 18420-49-0). Pls Click Website Link as below: cas 18420-49-0 suppliers

Prev:Synthesis, characterization and palladium complex formation of pyridinium- and quinolinium-3-acetylides: mesomeric betaines or betaine-stabilized carbenes?
Next:Synthesis, growth, crystal structure, optical and third order nonlinear optical properties of quinolinium derivative single crystal: PNQI)