Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated CHLORIN E6 (cas 19660-77-6)
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Add time:09/07/2019 Source:sciencedirect.com
BackgroundPhotodynamic therapy (PDT) exploits the reaction between photosensitizer and irradiated light to generate potentially therapeutic reactive oxygen species such as singlet oxygen in cancer cells. We have reported several sugar-conjugated chlorins that express stronger antitumor effects in PDT than talaporfin sodium (TS), a second-generation photosensitizer clinically used in Japan. In this study, we developed a novel glucose-conjugated chlorin e6 (G-chlorin e6) and evaluated its antitumor effects.
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