Research ArticlesAccelerated Peritoneal Dialysis of Barbiturates, Diphenylhydantoin, and Salicylate

Add time:09/01/2019    Source:sciencedirect.com

A combination of anthranilic acid (1%) and N-myristyl-β-aminopropionic acid (0.25%), which had been previously found to accelerate peritoneal dialysis of salicylate, was found also to accelerate the removal of diphenylhydantoin, phenobarbital, pentobarbital, and amobarbital. N-Myristyl-β-aminopropionic acid alone was equally or nearly as effective as the combination for the barbiturates. Studies indicate that displacement of the drugs from binding sites on plasma proteins may be involved in the mechanism of action of these accelerators.

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