Substituent-dependent reactivity in aldehyde transformations: 4-(phenylethynyl)benzaldehydes versus simple benzaldehydes

Add time:07/16/2019    Source:sciencedirect.com

Effects of substituents on transformations of 4-(phenylethynyl)benzaldehydes and related benzaldehydes were analyzed in aldol and thiazolidine formation reactions. The aldol reaction of 4-cyanobenzaldehyde was 54-fold faster than that of 4-methoxybenzaldehyde. In contrast, the aldol reaction of 4-(4-cyanophenylethynyl)benzaldehyde was only 1.4-fold faster than that of 4-(4-methoxyphenylethynyl)benzaldehyde. Electronic features of substituents are significantly less influential in a diphenylacetylene system than in a simple benzene system.

We also recommend Trading Suppliers and Manufacturers of Benzaldehyde, 2-[(4-Methoxyphenyl)ethynyl]- (cas 176910-67-1). Pls Click Website Link as below: cas 176910-67-1 suppliers

Prev:[Cu(maloNHC)]-catalyzed synthesis of 2-aryl pyrazolo[5,1-a]isoquinolines by annulation of N′-(2-((trimethylsilyl)ethynyl)benzylidene)hydrazides with terminal aromatic alkynes
Next:1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk’s rule validation)