QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin (cas 19683-98-8) analogues: another example of an allosteric interaction
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Add time:09/06/2019 Source:sciencedirect.com
QSAR have been formulated for variations of TNP-470 and ovalicin (cas 19683-98-8) on various cell lines. In the examples of mouse lymphocyte cells and bovine endothelial cells the results suggest an allosteric interaction. These results are compared with the binding of nitrobenzene to hemoglobin in rats in vivo. Such a reaction does not occur with methionine aminopeptidase.
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