1,5,7-Triazabicyclo[4.4.0]dec-5-ene (cas 19689-19-1) (TBD) catalyzed Michael reactions

Add time:09/04/2019    Source:sciencedirect.com

1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10–20 mol % of TDB. These reactions are mild, fast, easy to perform, produce excellent yields and can occur in several solvents without the need for strictly anhydrous conditions.

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