Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides

Add time:08/31/2019    Source:sciencedirect.com

Unnatural bases, 2-amino-6-(2-thienyl)purine and 2-amino-6-(2-furanyl)purine, were newly designed to replace the previously developed purine analogue, 2-amino-6-(N,N-dimethylamino)purine, which specifically pairs with pyridin-2-one. These nucleoside derivatives were synthesized via the 6-substitution of 6-iodopurine nucleosides with tributylstannylthiophene or tributylstannylfuran. As compared with 2-amino-6-(N,N-dimethylamino)purine, 2-amino-6-(2-thienyl)purine reduced the interference in the stacking interactions with the neighboring bases in a DNA duplex and improved the efficiency of the enzymatic incorporation of the nucleoside triphosphate of pyridin-2-one opposite the unnatural base.

We also recommend Trading Suppliers and Manufacturers of 2-Amino-6-iodopurine (cas 19690-23-4). Pls Click Website Link as below: cas 19690-23-4 suppliers

Prev:Synthesis and Co(III) complexes of the new tetradentate mixed-donor tetraamine ligand N-{2-[(2-pyridin-2-ylethyl)amino]ethyl}ethane-1,2-diamine (peda)
Next:Alterations in purine nucleotide biosynthesis induced by 2-amino-6-chloropurine☆)