Laboratory noteSynthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives

Add time:08/31/2019    Source:sciencedirect.com

4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from 1H and 13C NMR spectra. These drugs were tested against selected gram−, gram+ and mycobacteria strains. A promising activity was observed against Mycobacterium smegmatis.

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