Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK-912 (cas 111466-41-2): an O-analogue of the Pictet-Spengler reaction

Add time:09/04/2019    Source:sciencedirect.com

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet-Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

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