Biotransformation rates of Ugilec 141 (cas 111483-93-3)® (tetrachlorobenzyltoluenes) in rat and trout microsomes

Add time:09/02/2019    Source:sciencedirect.com

In vitro biotransformation rates of tetrachlorobenzyltoluene (TCBT) isomers 3,3′,4,4′-Cl4-2-Me (TCBT 87), 3,3′,4,4′-Cl4-5-Me (TCBT 88), and 3,3′,4′,5-Cl4-4-Me (TCBT 94) were determined using trout and rat hepatic microsomes. The disappearance of the TCBTs from the in vitro system followed first-order kinetics. The estimated biotransformation constants (k) for the rat ranged from 0.96 to 4.14 h−1. Biotransformation rates for trout microsomes were much lower and ranged from 0.009 to 0.017 h−1.

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