Research paperComplex formation reactions of gallium(III) and iron(III/II) with l-proline-thiosemicarbazone hybrids: A comparative study

Add time:09/01/2019    Source:sciencedirect.com

Three new gallium(III) and iron(III) complexes with l-proline-thiosemicarbazone hybrids, namely [GaCl(l-Pro-FTSC–2H)]·0.7H2O·0.5CH3OH (1·0.7H2O·0.5CH3OH), [GaCl(dm-l-Pro-FTSC–2H)]·0.4H2O (2·0.4H2O) and [FeCl(l-Pro-FTDA–H)]Cl (3) were synthesised and comprehensively characterised by spectroscopic methods (1H, 13C NMR, UV–vis), ESI mass spectrometry and X-ray crystallography. The complexes are soluble in biological media to allow for assaying their antiproliferative activity. The complexes were tested in three human cancer cell lines, namely HeLa, A549 (non-small cell lung cancer), LS174 and nontumorigenic MRC5. Complex formation equilibrium processes of l-Pro-FTSC with gallium(III), iron(II) and iron(II) ions were investigated in solution. The formation of mono-ligand iron(II) and gallium(III) complexes with pentadentate ligands and relatively low aqueous solution stability was found. Between iron(III) and the ligands, a redox reaction takes place via the oxidative cyclisation of the thiosemicarbazone.

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