Increased serotonin platelet uptake after tianeptine administration in depressed patients

Add time:09/05/2019    Source:sciencedirect.com

Tianeptine is a new antidepressant drug reported to enhance serotonin (5-hydroxytryptamine [5-HT] uptake in rat brain. The effect of tianeptine on 5-HT platelet uptake was studied in 10 depressed patients treated for 28 days. Tianeptine increases Vmax of 5-HT platelet uptake during treatment without inducing any change in Km. As early as 2 hr after the first administration, Vmax increased significantly (+ 23%, α = 0.01). Although of a lesser magnitude. 5-HT platelet uptake remains increased after chronic administration (+ 14% on day 10 and + 13% on day 28). This suggests that tianeptine affects 5-HT platelet uptake sites, either directly or via an action on modulators of 5-HT uptake. These results, in contrast with the action of other tricyclic antidepressants, confirm the original action of tianeptine on 5-HT platelet metabolism.

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