Concurrent BULLATINE A (cas 1354-84-3) enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors

Add time:09/01/2019    Source:sciencedirect.com

Ethnopharmacological relevanceBULLATINE A (cas 1354-84-3), a C20-diterpenoid alkaloid and one of the major effective ingredients in Aconiti brachypodi Radix (Xue-shang-yi-zhi-hao), can block pain hypersensitivity in a variety of rodent models through expression of spinal microglial dynorphin A.

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