Identification of the actinorhodin (cas 1397-77-9) monomer and its related compound from a deletion mutant of the actVA-ORF4 gene of Streptomyces coelicolor A3(2)

Add time:09/05/2019    Source:sciencedirect.com

An oxygenated derivative of dihydrokalafungin (DHK) was isolated from a deletion mutant of the actVA-ORF4 gene involved in the biosynthesis of a dimeric benzoisochromanequinone (BIQ) antibiotic, actinorhodin (cas 1397-77-9) (ACT), in Streptomyces coelicolor A3(2). Spectroscopic analysis elucidated its structure as 8-hydroxy-DHK, corresponding to the monomeric unit of ACT. Further metabolite analysis identified its related compound, clearly derived from the reduction of 8-hydroxy-DHK. The structures of these metabolites indicate the essential role of ActVA-ORF4 in ACT biosynthesis, specifically in dimerization of a BIQ intermediate via C–C bond formation.

We also recommend Trading Suppliers and Manufacturers of actinorhodin (cas 1397-77-9). Pls Click Website Link as below: cas 1397-77-9 suppliers

Prev:Original articleγ actinorhodin (cas 1397-77-9) a natural and attorney source for synthetic dye to detect acid production of fungi
Next:Crystal Structures of the Streptomyces coelicolor TetR-Like Protein ActR Alone and in Complex with actinorhodin (cas 1397-77-9) or the actinorhodin (cas 1397-77-9) Biosynthetic Precursor (S)-DNPA)