NoteIsolation and identification of a common intermediate produced by blocked mutants from β-rhodomycin (cas 1401-16-7) and daunomycin producers

Add time:09/01/2019    Source:sciencedirect.com

Biosynthetically blocked mutants isolated from the β-rhodomycin-producing Streptomyces violaceus A262 strain SC-7 and daunomycin-producing Streptomyces sp. D788 strain G1-1 were found to accumulate maggiemycin in their culture broths. Bioconversion tests using mutants that did not produce these antibiotics also proved that maggiemycin is a common precursor in the biosynthesis of β-rhodomycin and daunomycin.

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