Conformational change on calcium binding by the lipopeptide antibiotic Amphomycin (cas 1402-82-0). A C.D. and monolayer study

Add time:09/02/2019    Source:sciencedirect.com

The acidic linear lipopeptide amphomycin is a calcium dependent antibiotic which is thought to bind to carrier lipids such as dolichol monophosphate. The actual role of Ca++ is not definitely established and in this article we have examined the peptides interactions with a range of divalent cations. By CD we have shown that a conformational change is induced by Ca++, Sr++ and Ba++ but not by Mg++, Zn++, Cd++ or Gd++. Monolayer studies show a decrease in molecular area and an increase in film stability when the subphase contains Ca++. The ensemble of results provides preliminary evidence for the formation of a β hairpin structure on ion binding (Ka (Ca++)= 2.4 × 103M−1) which could enhance amphomycin's bilayer solubility.

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