Antifungal antibiotic Hamycin (cas 1403-71-0) increases susceptibility of Candida albicans to phagocytosis by murine macrophages

Add time:09/01/2019    Source:sciencedirect.com

Hamycin (cas 1403-71-0) is an antifungal antibiotic produced by Streptomyces pimprina Thirum. In the present study, the effect of hamycin on (a) the phagocytosis of Candida albicans by murine peritoneal macrophages and (b) the cell surface hydrophobicity (CSH) of C. albicans was investigated. Addition of hamycin to the culture of macrophages and Candida cells increased the susceptibility of Candida cells to the phagocytosis by macrophages. Pretreatment of Candida cells with hamycin increased their vulnerability to killing by macrophages. Examination of physico-chemical properties of Candida cell surface showed a significant decrease in the CSH. These findings suggest that the binding of hamycin to Candida cells induces biochemical/physico-chemical alterations of the surface, so that it becomes more susceptible to phagocytosis by murine macrophages.

We also recommend Trading Suppliers and Manufacturers of Hamycin (cas 1403-71-0). Pls Click Website Link as below: cas 1403-71-0 suppliers

Prev:Research paperEvaluation of collagen/hydroxyapatite electrospun layers loaded with vancomycin, Gentamicin (cas 1403-66-3) and their combination: Comparison of release kinetics, antimicrobial activity and cytocompatibility
Next:Antileishmanial activity of Hamycin (cas 1403-71-0): A polyene antibiotic)