Synthesis and morphological reversion activity on srctsNRK cells of pyrimidinylpropanamide antibiotics, SPARSOMYCIN (cas 1404-64-4), sparoxomycin A1, A2, and their analogues
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Add time:09/08/2019 Source:sciencedirect.com
Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4–9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5–7) showed higher morphological reversion activities on srctsNMR cells than 2 and 3.
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