Metal-free and highly regioselective synthesis of N-heteroaryl substituted pyrazoles from α,β-unsaturated N-tosylhydrazones and heteroaryl chlorides

Add time:09/01/2019    Source:sciencedirect.com

A cascade cyclization/nucleophilic aromatic substitution (SNAr) reaction of α,β-unsaturated N-tosylhydrazones with N-heteroaryl chlorides was developed for the synthesis of N-heteroaryl pyrazole derivatives. This one-pot reaction provided bi(heteroaryl) derivatives in good to excellent yields and with excellent regioselectivity. The procedure is operationally simple and applicable to large-scale synthesis.

We also recommend Trading Suppliers and Manufacturers of N(alpha)-guanilhistamine (cas 18431-51-1). Pls Click Website Link as below: cas 18431-51-1 suppliers

Prev:Research articleComputational studies on N-phenyl pyrrole derivatives as MmpL3 inhibitors in Mycobacterium tuberculosis
Next:DABCO/AgOAc cooperatively catalyzed α-sulfenylation of isocyanoacetates with N-(sulfanyl)succinimides)