Novel mononuclear Pt2 + and Pd2 + complexes containing (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid as a multi-donor ligand. Synthesis, structure, interaction with DNA, in vitro cytotoxicity, and apoptosis

Add time:09/05/2019    Source:sciencedirect.com

New cytotoxic, mononuclear Pt and Pd coordination complexes featuring the planar, multi-donor ligand (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid (H2PPDA) have been synthesized under hydrothermal conditions (in water, at high temperature and pressure) and fully characterized. The complexes were proven to be isostructural by applying the single-crystal X-ray diffraction technique. UV–Vis and fluorescence spectroscopy investigations on their interaction with fish sperm DNA revealed a considerable binding capacity while gel electrophoresis provided evidence in favor of cleavage of pBR322 plasmid DNA. The newly synthesized complexes manifested significant in vitro cytotoxic activity against two different human cancer cell lines, the KB and JEKO cells, with cell death mainly caused by apoptosis.

We also recommend Trading Suppliers and Manufacturers of DICHLORO(1,10-PHENANTHROLINE)PLATINUM(II) (cas 18432-95-6). Pls Click Website Link as below: cas 18432-95-6 suppliers

Prev:Synthesis, characterization, photophysical and electrochemical properties of fac-tricarbonyl(4,7-dichloro-1,10-phenanthroline)rhenium(I) complexes
Next:Case reportFatal cases of acute suicidal sodium and accidental zinc fluorosilicate poisoning. Review of acute intoxications due to fluoride compounds)