Sulfated polysaccharides from Rhodiola sachalinensis reduce d-gal-induced oxidative stress in NIH 3T3 cells

Add time:09/04/2019    Source:sciencedirect.com

In this study, three sulfated polysaccharides (S-RSP1–2, S-RSP1–4 and S-RSP1–8) from Rhodiola sachalinensis were produced by chlorosulfonic acid-pyridine method. d-gal was used to develop an oxidative stress model in the mouse embryonic fibroblast cell line NIH 3T3. Effects of the three sulfated polysaccharides on d-gal-induced oxidative stress were investigated. The results showed that S-RSP1–4 improved the viability of the d-gal-induced oxidative stress in NIH 3T3 cells. The sulfated polysaccharides were found to have a better protective effect against d-gal-induced oxidative stress as compared to the native polysaccharide. Scanning electronmicroscopy also showed a significant change in the surface morphology of sulfated polysaccharides. In addition, the sulfated polysaccharides had noticeable DPPH radical-scavenging activity. In summary, our results demonstrated that d-gal was able to induce oxidative stress in NIH 3T3 cells, and sulfated group might play an important role in resistance to d-gal-induced oxidative damage.

We also recommend Trading Suppliers and Manufacturers of (S)-Propane-1,2-diamine sulfate (cas 136370-46-2). Pls Click Website Link as below: cas 136370-46-2 suppliers

Prev:The role of sulfate and its corresponding S(IV)+NO2 formation pathway during the evolution of haze in Beijing
Next:Sulfated modification of arabinogalactans from Larix principis-rupprechtii and their antitumor activities)