Asymmetric synthesis of the mC7N core of the manumycin family: Preparation of (+)-MT 35214 and a formal total synthesis of (−)-alisamycin (cas 136398-54-4)

Add time:09/02/2019    Source:sciencedirect.com

An asymmetric approach to the mC7N epoxyquinone central unit of the manumycin antibiotics is described based on the enantioselective (89% ee) chiral phase transfer epoxidation of a substituted cyclohexenone. The chiral epoxide is employed in the first syntheses of the title compounds in enantiomerically pure form.

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