Inhibition of aminopeptidases by N-aminoacyl-O-4-nitrobenzoyl hydroxamates
-
Add time:09/03/2019 Source:sciencedirect.com
10 N-aminoacyl-O-4-nitrobenzoyl hydroxamates were investigated as potential inhibitors of aminopeptidases. While the metal-depending enzymes aminopeptidase M. aminopeptidase P and leucine aminopeptidase were inhibited reversibly by the compounds, the thiol enzyme cathepsin H was inhibited efficiently in time-dependent reactions according to its substrate specificity. N-phenylalanyl-O-4-nitrobenzoyl hydroxamate was shown to be most effective, exhibiting a second-order-rate constant of inhibition of 31 766 M−1 s−1.
We also recommend Trading Suppliers and Manufacturers of (+-)-5-Ethoxy-1-(4-nitrobenzoyl)-2-pyrrolidinone (cas 136410-03-2). Pls Click Website Link as below: cas 136410-03-2 suppliers
Prev:Short communicationMonitoring the products of condensation of 4-nitrobenzoyl chloride and 2,4-diaminobenzenesulphonic acid by ion-pair high-performance liquid chromatography
Next:Short communicationDirect determination of 4-nitrobenzoyl chloride by high-performance liquid chromatography based on silanophilic interaction) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- H-Phe-O-(4-nitrobenzoyl)hydroxamate09/06/2019
- Six-coordinate monooxo molybdenum(VI) complexes with N-4-diethylaminosalicylidene-N′-4-nitrobenzoyl hydrazine and catechol ligands: preparation and spectroscopic properties09/05/2019
- Short communicationDirect determination of 4-nitrobenzoyl chloride by high-performance liquid chromatography based on silanophilic interaction09/04/2019
- Short communicationMonitoring the products of condensation of 4-nitrobenzoyl chloride and 2,4-diaminobenzenesulphonic acid by ion-pair high-performance liquid chromatography09/02/2019
- Synthesis of 3,4-dihydroquinazolin-4-one: selenium-catalyzed reductive N-heterocyclization of N-(2-nitrobenzoyl)amides with carbon monoxide09/01/2019
