BBA reportConformation of oxytocin studied by laser Raman spectroscopy

Add time:09/08/2019    Source:sciencedirect.com

The peptide backbone conformation and salient structural details of oxytocin were examined by laser Raman spectroscopy. Spectra were obtained in the solid phase, water, 2H2O, and dimethyl sulfoxide solutions. A distinct Amide I band was obtained at 1663 cm−1 for aqueous and deuterated samples and 1666 cm−1 for the solid sample. A relatively high frequency Amide III band at 1260 cm−1 was obtained. It is concluded that these Amide I and III bands arise from the “β-turn”-like conformation of oxytocin.The tyrosine side chain, according to the I850 cm−1/I830cm−1 intensity ratio, is exposed to the solvent. The S-S stretching vibration at 512 cm−1 indicates the conformation of C-C-S-S-C-C in the disulfide bridge of oxytocin in the ring is gauche-gauche-gauche.

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