Pheophorbide-a conjugates with cancer-targeting moieties for targeted photodynamic cancer therapy

Add time:09/02/2019    Source:sciencedirect.com

Pheophorbide-a, a non-selective photosensitizer, was conjugated with cancer-targeting moieties, such as folic acid, the CRGDLASLC peptide, the cRGDfK peptide and leuprorelin, for the purpose of targeted photodynamic cancer therapy. The cellular uptake of pheophorbide-a conjugates in cancer cells overexpressing the corresponding receptors of the targeting moieties was largely enhanced compared with that in the receptor-negative cells. In the study of in vitro photodynamic activity and selectivity of pheophorbide-a conjugates in the receptor-positive and receptor-negative cells, a pheophorbide-a conjugate, (14) with an αvβ6 ligand (CRGDLASLC) exhibited the highest selectivity in the positive FaDu cells. Targeted PDT with 14 induced cell death through apoptosis and morphological apoptosis-like characteristics. These results suggest that pheophorbide-a conjugate 14 could be utilized in selective photodynamic therapy for oral cancers primarily expressing the αvβ6 receptor.

We also recommend Trading Suppliers and Manufacturers of Pheophorbide A (cas 15664-29-6). Pls Click Website Link as below: cas 15664-29-6 suppliers

Prev:Sodium Pheophorbide A (cas 15664-29-6) has photoactivated fungicidal activity against Pestalotiopsis neglecta
Next:The photodynamic action of Pheophorbide A (cas 15664-29-6) induces cell death through oxidative stress in Leishmania amazonensis)