Synthesis and kinetic evaluation of 4-deoxy-4-phosphonomethyl-d-erythronate, the first hydrolytically stable and potent competitive inhibitor of ribose-5-phosphate isomerase

Add time:09/01/2019    Source:sciencedirect.com

4-deoxy-4-Phosphonomethyl-d-erythronate, an isosteric and hydrolytically stable analogue of the known ribose-5-phosphate isomerase inhibitor 4-deoxy-4-phospho-d-erythronate, was obtained by a 14-step synthesis from d-arabinose through an highly improved synthesis of the precursor 5-deoxy-5-phosphonomethyl-d-arabinose. The title compound appears as the first stable and potent competitive inhibitor of the enzyme catalyzed isomerization of ribose-5-phosphate to d-ribulose-5-phosphate (Ki=74 μM, Km/Ki=100), exhibiting only a 3-fold weaker inhibitory activity than its phosphate analogue.

We also recommend Trading Suppliers and Manufacturers of RIBOSE-5-PHOSPHATE BARIUM SALT (cas 15673-79-7). Pls Click Website Link as below: cas 15673-79-7 suppliers

Prev:The crystal structure of the inclusion complex of cyclo-maltoheptaose (β-cyclodextrin) with 3,3-DIMETHYLBUTYLAMINE (cas 15673-00-4)
Next:Synthesis and evaluation of new 4-phospho-d-erythronic acid derivatives as competitive inhibitors of spinach ribose-5-phosphate isomerase)