Determination of embutramide (cas 15687-14-6) in biological matrices by gas chromatography with nitrogen—phosphorus detection

Add time:09/01/2019    Source:sciencedirect.com

embutramide (cas 15687-14-6) is a general anesthetic having a strong narcotic effect on the central nervous system where it paralyzes the brain center that controls respiration. It is a constituent of T61, a veterinary euthanasia drug. This paper describes a gas chromatographic procedure using nitrogen—phosphorus detection for the determination of embutramide in biological matrices. The drug and the internal standard (ambucetamide) are extracted with dichloromethane under alkaline conditions. The method is linear from 100 to 3000 ng/ml. The within-day and day-to-day coefficients of variation range from 5.1 to 5.7% and from 9.1 to 10.0%, respectively. The recovery is above 80% while the minimum detectable level under the conditions described is 40 ng/ml analyzing a 1-ml or a 1-g aliquot of a sample (blood or tissue). The method is also applied to different samples from dogs euthanized with T61.

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