Proteomes analysis reveals the involvement of autophagy in AD-like neuropathology induced by noise exposure and ApoE4
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Add time:09/06/2019 Source:sciencedirect.com
BackgroundNoise is one of the most important environmental health hazards for humans. Environmental noise or apolipoprotein ε4 (ApoE4) can cause typical Alzheimer's disease (AD)-like pathological changes, which is characterized by progressive cognitive decline and neurodegenerative lesions. Gene–environment interactions may accelerate cognitive decline and increase AD risk. However, there is limited experimental evidence regarding the underlying mechanisms of noise-ApoE4 interactions and AD, which may be closely related to AD development.
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