An efficient and versatile route to the synthesis of 9,10-dihydro-3-formylphenanthrenes☆

Add time:09/04/2019    Source:sciencedirect.com

An innovative and efficient route to the synthesis of 9,10-dihydro-3-formylphenanthrenes 7 has been delineated through the ring transformation of 2-oxo-4-sec-amino-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles 4 with methyl glyoxaldimethylacetal 5 to masked 3-dimethoxymethyl-1-sec-amino-9,10-dihydrophenanthrene-3-carbonitriles 6 followed by deacetalation with Amberlyst 15 in excellent yields.

We also recommend Trading Suppliers and Manufacturers of 3-(DIMETHOXYMETHYL)-1H-PYRAZOLE (cas 111573-59-2). Pls Click Website Link as below: cas 111573-59-2 suppliers

Prev:Preliminary communicationConvenient synthesis of [η3-1- (formyl)allyl]- and [η3-1- (dimethoxymethyl)allyl]palladium chlorides
Next:Synthesis of 5-substituted-3-[(2′S,3′S)-3′-hydroxy-2′-hydroxymethyltetrahydrofuran-3′-yl]-1,2,4-oxadiazoles and their epimers)