Short communicationSynthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors

Add time:09/02/2019    Source:sciencedirect.com

In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC50 values in the micromolar range.

We also recommend Trading Suppliers and Manufacturers of 1-((4-amino-2-methyl-5-pyrimidinyl)methyl)-3-(2-hydroxyethyl)-2-methyl-4-nitroimidazolium (cas 111607-65-9). Pls Click Website Link as below: cas 111607-65-9 suppliers

Prev:Three-component reaction of imidazoles, cyanophenylacetylene, and chalcogens: stereoselective synthesis of 3-alkenyl-2-imidazolethiones and -selones
Next:Target-site resistance to bensulfuron-methyl in Sagittaria trifolia L. populations)