Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands
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Add time:09/07/2019 Source:sciencedirect.com
Here we report the design and synthesis of spiro[pyrrolidine-3,3′-oxindole] derivatives representing a novel scaffold of 5-HT7 receptor ligands. The synthesized analogues were validated as low nanomolar ligands showing selectivity in a panel of related serotonin receptor subtypes including 5-HT1AR, 5-HT2AR and 5-HT6R.
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