Effect of scavengers in acidolytic cleavage of Cys(Acm)-containing peptides from solid support: Isolation of an ethanedithiol disulfide adduct

Add time:09/03/2019    Source:sciencedirect.com

Acidolytic cleavage of C-terminal Cys(Acm)-containing tripeptides from the Wang (HMP) resin can lead to partial deprotection of the Acm group and subsequent disulfide formation. The presence of water and the type of scavenger used in the cocktail mixture were found to play a role in the extent of these impurities formed.

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