The effect of single and combined doses of chlordimeform and permethrin on cAMP and cGMP levels in the moth, Mamestra configurata Wlk☆

Add time:09/24/2019    Source:sciencedirect.com

Treatment of adult males of the moth, Mamestra configurata, with chlordimeform caused large increases (up to 27-fold) in the concentration of cAMP in the head, thorax, and abdomen but had little effect on cGMP. This pesticidal effect, termed A+G0, likely results from the interaction of chlordimeform (or a metabolite) with an octopamine-sensitive adenylate cyclase present in the brain and other tissues. Treatment of moths with permethrin caused substantial increases (up to 3.4-fold) in the concentration of cGMP in the head and thorax but had little effect on cAMP. This effect, termed A0G+, may result from a disturbance of cholinergic function. Treatment of moths with a combined dose of chlordimeform and permethrin caused increases in the concentration of both cAMP and cGMP (A+G+ effect) in the head and thorax and had a synergistic effect on mortality. The synergistic effect on mortality appears to be caused by the disruption of distinct and different physiological systems by the A+G0 and A0G+ pesticides. The hypothesis that A+G0 and A0G+ pesticides, when combined, will exhibit synergism is supported by examples from the literature.

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