Z-Gln(Trt)-Aib-Aib-Aib-OMe synthesis using UNCA and BOP/PyBroP coupling methods

Add time:07/12/2019    Source:sciencedirect.com

The steric hindered Aib-Aib-Aib tripeptide was synthesized in mild conditions, using PyBroP for the coupling of two Aib and Fmoc-Aib-NCA for the generation of the tripeptide, which was obtained with an excellent yield in THF. The coupling of Gln was carried out in the presence of BOP.

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