“Fries like” rearrangement: A novel and efficient method for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones

Add time:09/02/2019    Source:sciencedirect.com

6-acyl-2(3H)-benzoxazolone and 6-acyl-2(3H)-benzothiazolone derivatives have particularly interesting anti-inflammatory, antiepileptic, analgesic and antiviral properties. In this study, we report an original method of acylation on the 6-position of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone which consists in a two-step procedure involving migration of the acyl group from the N-position to the 6-position of the heterocycle, at 165°C and catalyzed by AlCl3. This new procedure was found to be more efficient with regard to the consumption of AlCl3 and the yield (76–90%) than other acylation methods previously described.

We also recommend Trading Suppliers and Manufacturers of 6-benzoylbenzothiazolin-2-one (cas 133044-31-2). Pls Click Website Link as below: cas 133044-31-2 suppliers

Prev:Spiroborate catalyzed reductions with N,N-diethylaniline borane
Next:2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives: Novel, potent and selective σ1 receptor ligands)