Synthesis of oxazino[4,3-a]indoles by domino addition-cyclization reactions of (1H-indol-2-yl)methanols and vinyl selenones in the presence of 18-crown-6

Add time:09/03/2019    Source:sciencedirect.com

Herein we report the synthesis of biologically relevant oxazino[4,3-a]indoles by an environmentally friendly Michael addition-cyclization cascade using potassium hydroxide in dichloromethane employing variously substituted vinyl selenones and (1H-indol-2yl)methanols.The addition of 18-crown-6, as a complexing agent, is crucial to achieve high chemo- and regio-selectivity.

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