NoteA comparative study of different glycosylation methods for the synthesis of d-mannopyranosides of Nα-fluorenylmethoxycarbonyl-trans-4-hydroxy-l-proline allyl ester

Add time:09/03/2019    Source:sciencedirect.com

The synthesis of Nα-fluorenylmethoxycarbonyl-trans-4-hydroxy-4-O-[(2,3,4,6-tetra-O-acetyl)-α-d-mannopyranosyl]-l-proline allyl ester and Nα-fluorenylmethoxycarbonyl-trans-4-hydroxy-4-O-[(2,3,4,6-tetra-O-benzoyl)-α-d-mannopyranosyl]-l-proline allyl ester is described. Glycosylation using Königs–Knorr conditions with a benzoyl protected glycosyl donor provided the optimum method. Removal of the allyl ester gave two mannosylated building blocks suitable for solid phase glycopeptide synthesis.

We also recommend Trading Suppliers and Manufacturers of N-Fmoc-L-threonine Allyl Ester (cas 136523-92-7). Pls Click Website Link as below: cas 136523-92-7 suppliers

Prev:The effect of replacing the ester bond with an amide bond and of overall stereochemistry on the activity of daptomycin
Next:A general method for functionalising both the C- and N-terminals of Tyr3-octreotate)